Guides · 34

Peptide guides.

Concepts explained with judgement and sources — the foundational knowledge, free. The full master's goes much further.

• "Wolverine Blend": what the BPC-157 + TB-500 combination isWhat the so-called "Wolverine Blend" (BPC-157 + TB-500) refers to, why the two are combined and what the preclinical evidence says — explained educationally, no dosing, no medical advice.
• BPC-157 vs TB-500: how they differBPC-157 and TB-500 are both studied for tissue repair, but through different mechanisms. An educational comparison of origin, action and status, with no dosing.
• BPC-157: what it is and what is being researchedWhat BPC-157 is, which mechanisms are studied preclinically, where the evidence actually stands and what its legal status is — explained clearly, cautiously and educationally.
• CJC-1295 and Ipamorelin: what they are and how they workWhat each peptide is, why they are researched together on the GH axis, and what the evidence says — explained educationally, with no dosing or medical advice.
• CJC-1295 vs Sermorelin: two GHRH analogsCJC-1295 and sermorelin are both GHRH analogs acting on the same pituitary receptor. The key difference is duration of action. An educational comparison, with no dosing.
• Epitalon and longevity: what it is and what's being researchedWhat Epitalon is (the Ala-Glu-Asp-Gly tetrapeptide), what's studied about telomerase, the pineal gland and aging, and why the evidence calls for caution.
• GHK-Cu vs Epitalon: two approaches to longevityAn educational comparison of GHK-Cu and Epitalon: two peptides tied to aging that act through very different routes — copper signaling and tissue repair versus telomerase and pineal regulation. No dosing.
• GHK-Cu: what it is and what it's studied for (educational guide)What GHK-Cu is, the copper tripeptide Gly-His-Lys, what is researched about it, and how topical cosmetic use differs from research-grade material.
• GLP-1: semaglutide and tirzepatide explainedWhat the GLP-1 system is, how semaglutide and tirzepatide differ, and why they are prescription drugs — an educational, cautious guide with no dosing.
• How to read a peptide certificate of analysis (CoA)What a CoA is, what it measures (HPLC purity, mass-spec identity, quantification, contaminants) and how to judge whether the document truly matches your vial.
• How to reconstitute a peptide: a step-by-step guideWhat reconstituting a lyophilized peptide means, what materials are involved and how concentration is calculated — explained clearly and educationally, with no dosing recommendations.
• How to spot fake or low-quality peptidesSigns of material with no traceability, what underfill is and why quantification matters — criteria to judge quality, with no brand recommendations.
• How to store peptides: preserving lyophilized powder and solutionHow to store a lyophilized peptide, the reconstituted solution and bacteriostatic water — temperatures, light and common mistakes, explained educationally.
• Ipamorelin vs Sermorelin: two routes to the same axisAn educational comparison of Ipamorelin and Sermorelin: two growth-hormone secretagogues that act on different receptors of the same axis. No dosing and no medical advice.
• MK-677 vs Ipamorelin: oral vs injectableAn educational comparison of MK-677 (Ibutamoren), an oral non-peptide secretagogue, and Ipamorelin, an injectable peptide. Mechanism, route, duration of action and regulatory status — with no dosing guidance.
• MOTS-c: what it is and what it is researched forWhat MOTS-c is, a mitochondrial-derived peptide, what is studied about metabolism, insulin and exercise, and where the evidence stands — explained educationally.
• Peptides and sleep: what the evidence saysWhich peptides have been studied in relation to sleep, why the DSIP name promises more than the evidence supports, and where sleep hygiene stands against any shortcut.
• Peptides for cognition: an evidence-based overviewWhich peptides are studied as nootropics —Semax, Selank and Dihexa—, what mechanisms they represent, how much real evidence each one has, and why skepticism toward cognitive hype is warranted.
• Peptides for fat loss: what the science saysAn educational overview of the peptides and drugs studied in the context of fat loss: what has solid evidence, what is experimental, and why there are no shortcuts. Not medical advice or a protocol.
• Peptides for longevity: an evidence-based overviewWhich peptides are studied in longevity and healthspan research, what mechanisms are proposed and how strong the actual evidence is — an educational, skeptical overview, with no dosing and no promises.
• Peptides for recovery and injury: a research overviewWhich peptides are studied in tissue repair and recovery, what mechanisms they represent, and why the evidence is mostly preclinical rather than clinical.
• Peptides for skin: science-based cosmeticsWhich peptides are used in topical cosmetics (GHK-Cu, Matrixyl, Argireline), what is studied about each, and what to realistically expect — a cautious, educational, informed-consumer guide, with no promises.
• PT-141 (Bremelanotide): what it is and what is being researchedWhat PT-141 or bremelanotide is, how its central mechanism differs from Viagra's, what has been approved (Vyleesi) and what its real status is — explained clearly, cautiously and educationally.
• PT-141 vs Melanotan-2: how they differPT-141 and Melanotan-2 come from the same melanocortin program, but they are different molecules with very different safety profiles and regulatory status. An educational comparison, with no dosing.
• Retatrutide vs Tirzepatide: dual vs triple agonistHow retatrutide (a triple GIP/GLP-1/glucagon agonist, still investigational and NOT approved) differs from tirzepatide (a dual GIP/GLP-1 agonist, already approved). An educational comparison, with no dosing and no medical advice.
• Semaglutide vs Tirzepatide: how they differAn educational comparison of semaglutide and tirzepatide: mechanism, approved brands, indications and clinical programs. Both are prescription drugs; this is not medical advice or a recommendation for use.
• Semax and Selank: what these Russian nootropic peptides areWhat Semax and Selank are, what each is researched for, how they differ, and the state of their evidence and regulatory status — explained educationally.
• TB-500 vs Thymosin Beta-4: why they are not the sameTB-500 and Thymosin Beta-4 are sold as interchangeable, but they are different molecules. We explain the fragment-versus-full-protein distinction, educationally.
• Tesamorelin vs CJC-1295: approved vs experimentalBoth are GHRH analogs that stimulate growth hormone, but one is an FDA-approved drug and the other is research material. An educational comparison, with no dosing.
• Tesamorelin: what it is and what it was approved forWhat tesamorelin is, how it acts on the growth-hormone axis, the specific indication the FDA approved it for and why use outside that indication is not approved — explained clearly, cautiously and educationally.
• Thymosin Alpha-1 vs Beta-4: two different moleculesThey share the 'thymosin' family name, but Alpha-1 and Beta-4 are different peptides, with different structure, function and regulatory status. An educational comparison, no dosing.
• Tirzepatide: what it is and how it worksWhat tirzepatide is, how it works as a dual GLP-1/GIP agonist, which brands are approved and why the distinction between the prescription medicine and gray-market material is critical — explained clearly, cautiously and educationally.
• What is a peptide: definition, types and why they are studiedWhat a peptide is, how it differs from a protein, which ones are endogenous or synthetic and why they are researched — explained clearly and educationally.
• What is bacteriostatic water and what is it used forWhat bacteriostatic water is, what it is used for when reconstituting lyophilized powders, and how it differs from sterile and distilled water — explained clearly and educationally.